ncRNA name | VEGF shRNA |
ncRNA Category | shRNA |
Disease name | age-related macular degeneration (AMD) |
Species | Homo sapiens |
Tissues/Cell_line | human RPE cell line ARPE-19 |
Methods | shRNA knockdown, luciferase reporter assay, RT‐PCR |
Expression pattern | associated |
Functional description | The three most potent shRNA‐expressing constructs, sh5, sh7 and sh9, significantly reduced RLuc‐VEGF reporter activity (from 80 to 86%, see Manuscript III) in co‐transfected ARPE‐19 cells in the dual‐luciferase‐based translation assay. |
PubMed ID | 24953666 |
Year | 2014 |
Title | Development of gene therapy for treatment of age-related macular degeneration. |
Drug-related ncRNA | NA |
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