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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of age-related macular degeneration (AMD)
ncRNA name VEGF shRNA
ncRNA Category shRNA
Disease name age-related macular degeneration (AMD)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods shRNA knockdown, luciferase reporter assay, RT‐PCR
Expression pattern associated
Functional description The three most potent shRNA‐expressing constructs, sh5, sh7 and sh9, significantly reduced RLuc‐VEGF reporter activity (from 80 to 86%, see Manuscript III) in co‐transfected ARPE‐19 cells in the dual‐luciferase‐based translation assay.
PubMed ID 24953666
Year 2014
Title Development of gene therapy for treatment of age-related macular degeneration.
Drug-related ncRNA NA

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